Antiphospholipid Syndrome Presenting as Massive Pulmonary Embolism in a Patient with Sarcoidosis
نویسندگان
چکیده
Sarcoidosis is a systemic, chronic disease of unknown etiology that is characterized by non-caseating granulomas in any tissue. Impairment of cellular immunity is known to play a major role in this disease. Humoral abnormalities such as the occasional presence of anti double-stranded DNA (antids DNA), antinuclear antibody (ANA) and rheumatoid factor (RF) have also been observed in patients with sarcoidosis but the clinical significance of these autoantibodies is not known (1-3). Although the presence of antiphospholipid antibodies (APLA) have been reported, the occurrence of antiphospholipid syndrome (APS) seems rare. Herein, we report a case of massive pulmonary embolism due to APS with additional thrombotic risk factors who also had multiple mediastinal and hilar adenopathies that were diagnosed as sarcoidosis.
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